severe hypercalcemia: a rare and unusual presentation of childhood acute lymphoblastic leukemia.

Severe Hypercalcemia: A Rare and Unusual Presentation of Childhood Acute Lymphoblastic Leukemia

Hypercalcemia in children is a medical emergency and often manifests as nonspecific symptoms such as nausea, vomiting, weight loss, and anorexia. Severe hypercalcemia is a rare complication of malignancy in children, while it can be seen in various types of malignant tumors. It is usually associated with significant morbidity and may be severe enough to threaten life. Incidence of hypercalcemia...

Osteolytic bone lesions, severe hypercalcemia without circulating blasts: unusual presentation of childhood acute lymphoblastic leukemia

Hypercalcemia and severe osteolytic lesions are rare complications of acute lymphoblastic leukemia (ALL) in childhood. We report a case of a 3 years old boy who presented with prolonged fever, nausea, vomiting and increasing lower limbs pain. Skeletal X-rays and CT scan showed severe osteolytic lesions of the skull and extremities. Her physical examination showed multiple cervical lymph nodes. ...

Osteolytic Bone Lesions, Hypercalcemia, and Renal Failure: A Rare Presentation of Childhood Acute Lymphoblastic Leukemia

unusual presentation of relapsing acute lymphoblastic leukemia

purpose: to report an unusual ocular presentation of a relapse of acute lymphoblastic leukemia. case report: a 9-year-old girl presented with a subconjunctival mass and ipsilateral preauricular lymphadenopathy. she had history of acute lymphoblastic leukemia (all) in remission but had a normal blood cell profile. because of corneal dellen formation and enlargement of the mass over a 2-week peri...

Multiple Osteolytic Lesions Causing Hypercalcemia: A Rare Presentation of Acute Lymphoblastic Leukemia

Acute lymphoblastic leukemia is characterized by unchecked proliferation of malignant lymphoblasts which replaces the normal bone marrow culminating in anemia due to red blood cells inadequacy as well as in easy bruising/bleeding secondary to insufficient platelets production. Even the white blood cells which are produced excessively are immature and abnormal. ALL is the most common hematologic...

Reply to: Severe hypercalcemia as a form of acute lymphoblastic leukemia presentation in children

Hypercalcemia is a rare metabolic disorder in children and is potentially fatal. It has a wide differential diagnosis, including cancer. Here, we report the case of a previously healthy 3-year-old who was admitted to the emergency room with fatigue, hyporeactivity, fever and limping gait that had evolved over 5 days and that was progressively worsening. On examination the patient was unconsciou...